Tourette Syndrome

Tourette syndrome is a neurological disorder characterized by repetitive, involuntary movements and vocalizations called tics. Many individuals with Tourette syndrome lead normal lives, with tics often improving or changing in severity as they age.

  • Cause: The exact cause is unclear, but it is thought to involve a combination of genetic and environmental factors. It is believed to involve abnormalities in the brain areas that control movement.

  • Features: Tics can be motor (e.g., blinking, head jerking) or vocal (e.g., grunting, throat clearing, swearing). Tics often appear between the ages of 5-10 and can change in type and severity over time.

  • Diagnosis: Based on clinical symptoms, typically involving the presence of tics for at least one year. No specific test for Tourette syndrome.

  • Treatment: No cure, but treatment options include behavioral therapy (CBT) to manage tics and medications (e.g., antipsychotics, alpha-agonists) to control severe symptoms.

Active Trials

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Past Trials

  • TITLE: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Evaluate the Safety and Maintenance of Efficacy of Ecopipam in Children, Adolescents and Adults with Tourette’s Disorder.

    SPONSOR: Emalex Biosciences, Inc.

    INDICATION: Tourette’s Syndrome

    PROTOCOL: EBS-101-TD-301

    PHASE: 3

    DESCRIPTION: This Phase 3 multicenter study evaluates the maintenance of efficacy, safety and tolerability of ecopipam tablets in children, adolescents and adults in the treatment of Tourette's Disorder (TD). The study includes an open-label period followed by double-blind, placebo-controlled, randomized withdrawal period.

    STATUS: Active

    RECRUITING PATIENTS: No

    RDR LOCATION: Georgia